The star has given the complete sum of his £25k honor winnings to the trust for venues, which operates to preserve the UK's independent concert spaces.
Fender was presented with the prize on 16 October as his latest record People Watching was chosen as the outstanding release of the past year.
He has opted to donate the funds to the MVT, in appreciation of the essential function local spots had in his early career.
"I personally couldn't be pursuing my current career if it weren't for all the performances I did around the area, and further afield, when I was beginning," said Sam Fender. "These spaces are legendary, but they are struggling."
Beginning in 2023, over 150 of these spaces have ceased operations – roughly one-sixth of the total UK scene.
Over the past year, top acts like the band Pulp, Coldplay, Katy Perry and Ed Sheeran have all backed the Music Venues Trust in its efforts to support the industry, by including a modest fee to their admission fees, which benefits smaller concert halls.
Fender also joined in, raising more than £100,000 on his recent tour to assist thirty-eight small stages across Britain.
The money supported locations that were facing possible closure due to difficulties caused by flooding, fires and personal losses, as well as permit problems, conflicts and neighbor objections.
Some locations obtained monetary aid in upgrading amenities and gear that helped musicians and fans.
"The concept that revenue from performances in major spaces helps the local stages, where it kicks off for performers like me, is just logical," the star has commented.
Fender is not the first artist to donate his Mercury Prize funds to worthy causes.
Back when Pulp received the prize in the year 1996 for their release their work, vocalist Jarvis Cocker declared that the band would contribute their cash to the organization War Child.
During 2002, musician she shared her award among multiple charities, like the NSPCC and a charity for Sickle Cell.
"Additionally, I donated a £1,000 to my local community centre, to their classes, because I trained in gymnastics when I was a child and they lacked better apparatus," she told the media.
In recent years, the band donated their winnings to the youth organization that developed their band, in addition to other independent music bodies.
Also winners that year M People gave their winnings to a multiple sclerosis charity after a friend was diagnosed the illness.
"The victory was sufficient," stated artist the singer. "The money was the extra but we didn't require the cherry, because we had the main prize. So our success affected another person's life."
Recently, the trust announced it had rescued a couple of local spots in south-east England, by transferring them to public stewardship.
The Joiners in the city and the second in Bristol were acquired under the Own Our Venues program, which is funded by the arts council and enthusiasts who buy "stakes" in the properties.